Metabolomic analysis reveals metabolic characteristics of children with short stature caused by growth hormone deficiency

The diagnosis of short stature (SS) is of widespread important for later treatment. In this paper, a metabolomic method was used to analyze the metabolic characteristics of SS children caused by endocrine metabolic diseases in order to understand the underlying biochemical mechanism and provide a potential intervention strategy for SS. According to the clinical diagnosis and family investigation, all patients with SS were confirmed to be due to the endocrine disorders, especially GHD. A nuclear magnetic resonance (NMR)-based metabolomic analysis of serum was used to identify the metabolic changes of 45 SS children from the 35 healthy controls. The disturbed metabolic network related to SS was correspondingly derived from the differential metabolites. The SS children demonstrated the higher serum levels of citrate, phenylalanine, creatinine and tyrosine and lower serum levels of glucose, serine, betaine, inositol, lysine, glycerol and glutamine compared with the healthy controls. The results demonstrated that the disturbed glucose metabolism and metabolism and biosynthesis of amino acids are typical metabolic features of SS, and the lower levels of lysine and glutamine are the metabolic characterization of the affected growth axes and stress state of SS, respectively. The significant changes of those serum metabolites are able to be regarded as potential biomarkers for the diagnosis of SS. Accordingly, supplemental betaine in dietary pattern, the improvement of glycometabolism...
Source: Clinical Science - Category: Biomedical Science Authors: Tags: PublishAheadOfPrint Source Type: research