Serotonin receptor expression is dynamic in the liver during the transition period in Holstein dairy cows

Non-neuronal serotonin (5-HT) participates in glucose metabolism, but little is known regarding the actions of 5-HT in the liver during the transition period in dairy cattle. Here we explore circulating patterns of 5-HT, and characterize the hepatic 5-HT receptor and glucose transporter profiles around calving in multiparous Holstein dairy cows (n = 6, average lactation = 4 ± 1.9). Concentrations of serum 5-HT decreased on day -3 compared to -5 and -7 precalving (167.7 ± 80 vs. 1511.1 ± 602 ng/mL).
Source: Domestic Animal Endocrinology - Category: Endocrinology Authors: Source Type: research