Update on Systemic Therapy for Advance Prostate Cancer

In 1942 Huggins and Hodges published data establishing the role of androgens in prostate cancer by showing that inhibition of androgens lead to regression of advanced prostate cancer 1. Androgen deprivation remains the mainstay of treatment for metastatic prostate cancer or situations that are not amenable to local therapy. Androgen deprivation or castration takes place either by medical or surgical means. Clinically this is demonstrated by a testosterone level < 50ng/ml. Surgical castration is an efficient way to abruptly remove the source of androgens 2 and is a viable option for some men.
Source: Current Problems in Cancer - Category: Cancer & Oncology Authors: Source Type: research