S-nitrosylation and its role in breast cancer angiogenesis and metastasis

Publication date: Available online 9 March 2019Source: Nitric OxideAuthor(s): Pamela Ehrenfeld, Francisco Cordova, Walter N. Duran, Fabiola A. SanchezAbstractS-nitrosylation, the modification by nitric oxide of free sulfhydryl groups in cysteines, has become an important regulatory mechanism in carcinogenesis and metastasis. S-nitrosylation of targets in tumor cells contributes to metastasis regulating epithelial to mesenchymal transition, migration and invasion. In the tumor environment, the role of S-nitrosylation in endothelium has not been addressed; however, the evidence points out that S-nitrosylation of endothelial proteins may regulate angiogenesis, adhesion of tumor cells to the endothelium, intra and extravasation of tumor cells and contribute to metastasis.
Source: Nitric Oxide - Category: Chemistry Source Type: research