Sense and sensibility: ATM oxygen stress signaling manages brain cell energetics

The ataxia-telangiectasia mutated (ATM) gene regulates DNA damage repair, oxidative stress, and mitochondrial processes. In this issue, Chow et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201806197) connects ATM’s oxidative stress response functions to the sensing of metabolic ATP energetics distinctively important in high energy–demanding Purkinje brain cells, which could explain the most distinct A-T patient feature, cerebellar ataxia.

http://jcb.rupress.org/cgi/content/short/218/3/732?rss=1

Source: Journal of Cell Biology - March 3, 2019 Category: Cytology Authors: Schlacher, K. Tags: Spotlight Source Type: research