Previous hepatitis E virus infection, cirrhosis and insulin resistance in patients with chronic hepatitis C

ConclusionPatients with chronic hepatitis C are under risk of hepatitis E virus superinfection in Brazil. The trend toward association between cirrhosis and previous HEV infection suggests that it may accelerate liver fibrosis in patients with chronic hepatitis C. In addition, previous infection by HEV is independently associated with insulin resistance in the studied population, which may be an extra-hepatic manifestation of hepatitis E that persists after resolution of the active infection, and may contribute to fibrosis progression.
Source: The Brazilian Journal of Infectious Diseases - Category: Infectious Diseases Source Type: research