Vessel co-option in cancer

Vessel co-option in cancerVessel co-option in cancer, Published online: 28 February 2019; doi:10.1038/s41571-019-0181-9Despite much hope, anti-angiogenic agents have largely failed to achieve the promise demonstrated in preclinical models. In this Review, the authors discuss an alternative hypothesis — vessel co-option — that might explain many of these failures and describe the evidence for a role of this largely overlooked aspect of tumour biology.

Source: Nature Clinical Practice Oncology - February 28, 2019 Category: Cancer & Oncology Authors: Elizabeth A. Kuczynski Peter B. Vermeulen Francesco Pezzella Robert S. Kerbel Andrew R. Reynolds Source Type: research