Pneumocystis pneumonia in HIV-1-infected patients

Publication date: Available online 26 February 2019Source: Respiratory InvestigationAuthor(s): Satoshi Shibata, Toshiaki KikuchiAbstractPneumocystis pneumonia (PCP) is an opportunistic disease that mainly affects patients with a deficiency of cell-mediated immunity, especially acquired immunodeficiency syndrome (AIDS). The incidence of PCP in these patients has declined substantially owing to the widespread use of antiretroviral therapy and PCP prophylaxis. However, PCP is still a major AIDS-related opportunistic infection, particularly in patients with advanced immunosuppression in whom human immunodeficiency virus type 1 (HIV-1) infection remains undiagnosed or untreated. The clinical manifestations, diagnosis, treatment, and prevention of PCP in patients with HIV-1 infection are addressed in this review.
Source: Respiratory Investigation - Category: Respiratory Medicine Source Type: research