Methods for meta-analysis of genetic data.

Methods for meta-analysis of genetic data.
Curr Protoc Hum Genet. 2013;Chapter 1:Unit1.24
Authors: Lunetta KL
Abstract
Modern genetic association studies, using genome-wide genotype data, are often underpowered. Meta-analyses of multiple studies performing genome-wide genotyping improve power and have led to the identification of thousands of genotype-trait associations. This unit provides an overview of the key concepts required for genetic meta-analyses, and presents strategic approaches and key decisions that must be made in the process of performing genome-wide association study (GWAS) meta-analyses. The commentary discusses the interpretation of GWAS meta-analysis results, complications, and some of the possible next steps once a GWAS meta-analysis has successfully identified regions associated with a trait.
PMID: 23595597 [PubMed - indexed for MEDLINE]

Source: Current Protocols in Human Genetics - November 25, 2014 Category: Genetics & Stem Cells Tags: Curr Protoc Hum Genet Source Type: research