S100b counteracts neurodegeneration of rat cholinergic neurons in brain slices after oxygen-glucose deprivation.

S100b counteracts neurodegeneration of rat cholinergic neurons in brain slices after oxygen-glucose deprivation. Cardiovasc Psychiatry Neurol. 2010;2010:106123 Authors: Serbinek D, Ullrich C, Pirchl M, Hochstrasser T, Schmidt-Kastner R, Humpel C Abstract Alzheimer's disease is a severe chronic neurodegenerative disorder characterized by beta-amyloid plaques, tau pathology, cerebrovascular damage, inflammation, reactive gliosis, and cell death of cholinergic neurons. The aim of the present study is to test whether the glia-derived molecule S100b can counteract neurodegeneration of cholinergic neurons after oxygen-glucose deprivation (OGD) in organotypic brain slices of basal nucleus of Meynert. Our data showed that 3 days of OGD induced a marked decrease of cholinergic neurons (60% of control), which could be counteracted by 50 mug/mL recombinant S100b. The effect was dose and time dependent. Application of nerve growth factor or fibroblast growth factor-2 was less protective. C-fos-like immunoreactivity was enhanced 3 hours after OGD indicating metabolic stress. We conclude that S100b is a potent neuroprotective factor for cholinergic neurons during ischemic events. PMID: 20508809 [PubMed]
Source: Cardiovascular Psychiatry and Neurology - Category: Psychiatry Tags: Cardiovasc Psychiatry Neurol Source Type: research