Case series of post-thrombolysis patients undergoing hemicraniectomy for malignant anterior circulation ischaemic stroke.

Case series of post-thrombolysis patients undergoing hemicraniectomy for malignant anterior circulation ischaemic stroke. Cardiovasc Psychiatry Neurol. 2011;2011:254569 Authors: Williams A, Sittampalam M, Barua N, Mohd Nor A Abstract While ischaemic stroke remains a leading cause of death and disability, there have been recent advancements in treatment modalities including thrombolysis and decompressive hemicraniectomy. A retrospective review of patients treated in our NHS teaching hospital, in Plymouth (UK), over a 2 year period identified 17 thrombolysed patients, of whom two had undergone subsequent decompressive hemicraniectomy. These were non-dominant hemisphere strokes in young patients, aged 51 and 57. Initial NIHSS scores were 16 and 17, and they received thrombolysis at 2 hrs 42 min and 5 hrs 10 min post onset of symptoms respectively. CT imaging demonstrated cerebral swelling with significant midline shift in both cases, and decompressive hemicraniectomy was undertaken at 29 hrs 8 min and 27 hrs 30 min post-thrombolysis. We found no significant intra-operative complications attributable to prior use of thrombolytics. Both patients have had acceptable psychological and physical outcomes, with Barthel Index scores of 40 and 25, and MMSE scores of 29/30 and 27/30. We conclude that the use of thrombolytic therapy does not contra-indicate subsequent decompressive hemicraniectomy in well selected patients with non...
Source: Cardiovascular Psychiatry and Neurology - Category: Psychiatry Tags: Cardiovasc Psychiatry Neurol Source Type: research