FNDC5/Irisin inhibits pathological cardiac hypertrophy

In conclusion, we find irisin is secreted in an ADAM family dependent manner, and irisin treatment improves cardiac function and attenuates pressure overload-induced cardiac hypertrophy and fibrosis mainly through regulating AMPK-mTOR signaling.

Source: Clinical Science - February 19, 2019 Category: Biomedical Science Authors: Yu, Q., Kou, W., Xu, X., Zhou, S., Luan, P., Xu, X., Li, H., Zhuang, J., Wang, J., Zhao, Y., Xu, Y., Peng, W.-h. Tags: PublishAheadOfPrint Source Type: research