Polyphenolic extracts of walnut (Juglans regia) green husk containing juglone inhibit the growth of HL-60 cells and induce apoptosis

ConclusionsGreen husk extract generate an antiproliferative effect in HL-60 cells, related with an induction of the early stages of apoptosis and a loss of mitochondrial membrane potential. The normal cells were not affected when juglone is present in concentrations of 1 μM, while at higher concentrations there is loss of viability of both cancerous and healthy cells.
Source: Electronic Journal of Biotechnology - Category: Biotechnology Source Type: research