In Vitro Method of Studying the Angiotensin Activity of Chemical Compounds.

In Vitro Method of Studying the Angiotensin Activity of Chemical Compounds.
Bull Exp Biol Med. 2014 Nov 19;
Authors: Spasov AA, Yakovlev DS, Bukatina TM, Brigadirova AA
Abstract
We developed and tested an experimental model to study in vitro the type 1 angiotensin antagonistic activity of compounds on the isolated portal vein of rats. The reliability of this method was confirmed in tests with saralasin (nonselective antagonist of angiotensin receptors) and losartan (selective antagonist of type 1 angiotensin receptors) in concentrations of 10(-9)-10(-5) mol/liter. The half-maximal inhibitory concentrations (IC50) of these substances were calculated.
PMID: 25403411 [PubMed - as supplied by publisher]

Source: exp Mol Med - November 19, 2014 Category: Molecular Biology Authors: Spasov AA, Yakovlev DS, Bukatina TM, Brigadirova AA Tags: Bull Exp Biol Med Source Type: research