An airway organoid is forever

In the last decade, the generation and maintenance of organotypic structures has been propelled to the center stage of biomedical research. In the lung, a variety of protocols has been devised to generate organoids mimicking lung structures, but most methods with human cells have complicated lengthy protocols or a progressive decline in differentiation potential and physiological function with increasing passaging. A new study from Sachs et al (2019) seeks to solve these issues, providing a versatile methodology to efficiently isolate, indefinitely culture, and manipulate human airway organoids, potentially allowing the in vitro modeling of a plethora of lung diseases.
Source: EMBO Journal - Category: Molecular Biology Authors: Tags: Development & Differentiation, Methods & Resources, Molecular Biology of Disease News [amp ] Views Source Type: research