BRCA Exchange Available on the Web; Understanding BRCA Variants

It's not known among some healthcare consumers that there are a host of BRCA variants other than the standard ones. Normal BRCA testing looks forthree specific genetic variants that are linked to hereditary cancers. Two of these variants — 185delAG and 5382insC — are in the BRCA1 gene. One variant — called 6174delT — is in the BRCA2 gene. A patient may test positive for a variant other than these common ones and it may not be clear under such circumstances what treatment to offer to the patient. The BRCA Exchange is now avai lable on the web that may be of assistance to researchers, physicians, and patients in understanding these variants (see:BRCA Exchange aggregates data on thousands of BRCA variants to inform understanding of cancer risk), Below is an excerpt from the article about this new web reference site:A global resource that includes data on thousands of inherited variants in the BRCA1 and BRCA2 genes is available to the public. TheBRCA Exchange was created through theBRCA Challenge, a long-term demonstration project initiated by theGlobal Alliance for Genomics and Health (GA4GH) to enhance sharing of BRCA1 and BRCA2 data. The resource, available through a website and a new smartphone app, allows clinicians to review expert classifications of variants in these major cancer predisposition genes as part of their individual assessment of complex questions related to cancer prevention, screening, and intervention for high-risk patients....Certain...
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