Physiological and pathological levels of Prostaglandin E2 in renal parenchyma and neoplastic renal tissue

Publication date: Available online 10 February 2019Source: Prostaglandins & Other Lipid MediatorsAuthor(s): Vittore Verratti, Luigi Brunetti, Claudio Ferrante, Giustino Orlando, Lucia Recinella, Annalisa Chiavaroli, Sheila Leone, Run Wang, Francesco BerardinelliAbstractProstaglandin (PG)E2 seems to promote tumor proliferation by regulating cell growth, inhibiting apoptosis, promoting angiogenesis, and suppressing host immune surveillance of cancer cells. The suppression of prostaglandins biosynthesis is thought to be the main molecular mechanism for non-steroidal anti-inflammatory drugs antineoplastic effect. Yet the relationship between PGE2 and human renal cell carcinoma remains unclear. The aim of our study is to evaluate the PGE2 content in human renal parenchyma and Renal Cell Carcinoma. The study was conducted on 20 consecutive patients undergoing radical nephrectomy for Renal Cell Carcinoma. In the normal renal parenchyma and in the neoplastic renal tissue the PGE2 level was 83.43 ± 5.89 pg/mg and 289.67 ± 22.2 pg/mg, respectively (P < 0.0001). There was no relationship between PGE2 content and Renal Cell Carcinoma dimension, Fuhrman grade, pathological-Tumor-Node and Metastasis (pTNM) stage and histological subtype. The PGE2 over-content in neoplastic renal tissue suggests a role of PGE2 in development and progression of renal carcinoma.
Source: Prostaglandins and Other Lipid Mediators - Category: Lipidology Source Type: research