CXCR3 ligands in disease and therapy

Originally discovered to be chemotactic cytokines leading the way for leukocytes in health and inflammation, the chemokines have now made a name for themselves as pleiotropic molecules involved in a range of physiological as well as pathological processes [1,2]. Most of their effects are established by signaling through a set of chemokine receptors, typically G protein-coupled receptors (GPCR). Notably, chemokine ligand/receptor binding is both a promiscuous and a redundant interaction, meaning that a particular chemokine will show affinity for several chemokine receptors and a particular chemokine receptor can be activated by various chemokine ligands, respectively.

Source: Cytokine and Growth Factor Reviews - November 21, 2014 Category: Molecular Biology Authors: Katrien Van Raemdonck, Philippe E. Van den Steen, Sandra Liekens, Jo Van Damme, Sofie Struyf Tags: Survey Source Type: research