Conjoint regulation of glucagon concentrations via plasma insulin and glucose in dairy cows

Insulin and glucagon are glucoregulatory hormones that contribute to glucose homeostasis. Plasma insulin is elevated during normo- or hyperglycemia and acts as a suppressor of glucagon secretion. We have investigated if and how insulin and glucose contribute to the regulation of glucagon secretion through long term (48 h) elevated insulin concentrations during simultaneous hypoglycemia or euglycemia in mid lactating dairy cows. Nineteen Holstein dairy cows were randomly assigned to three treatment groups: an intravenous insulin infusion (HypoG, n=5) to decrease plasma glucose concentrations (2.5 mmol/L), a hyperinsulinemic euglycemic clamp to study effects of insulin at simultaneously normal glucose concentrations (EuG, n=6), and a 0.9 % saline infusion (NaCl, n=8).
Source: Domestic Animal Endocrinology - Category: Endocrinology Authors: Source Type: research