In Defense of Morphine (Part 2)

This study examined the effects of pre-PCI fentanyl on plasma concentrations of ticagrelor (another P2Y12 inhibitor) and platelet function. Guess what: it showed the same effect we’ve seen in morphine. Fentanyl delayed platelet inhibition with a lower area under the curve for the ticagrelor concentrations, but these differences narrowed after 4 hours. I prefer fentanyl and I think you should too. There are a lot of things to like about it, but please, don’t make unsubstantiated claims that morphine is hurting patients; it’s a lazy, myopic misuse of the evidence.   References  Meine TJ, Roe MT, Chen AY, Patel MR, Washam JB, Ohman EM, Peacock WF, Pollack CV Jr, Gibler WB, Peterson ED; CRUSADE Investigators. Association of intravenous morphine use and outcomes in acute coronary syndromes: results from the CRUSADE Quality Improvement Initiative. Am Heart J. 2005 Jun;149(6):1043-9. doi: 10.1016/j.ahj.2005.02.010. PMID: 15976786. Spiegel, R. A Case of Identity. https://emcrit.org/emnerd/a-case-of-identity/ Spiegel, R. A Case of Identity Part Two. https://emcrit.org/emnerd/case-identity-part-two/ Spiegel, R. The Case of the Inconsequential Truth. https://emcrit.org/emnerd/em-nerd-case-inconsequential-truth/ McEvoy JW, Ibrahim K, Kickler TS, Clarke WA, Hasan RK, Czarny MJ, Keramati AR, Goli RR, Gratton TP, Brinker JA, Chacko M, Hwang CW, Johnston PV, Miller JM, Trost JC, Herzog WR, Blumenthal RS, Thiemann DR, Resar JR, Schulman SP. Effect of Intravenous Fent...
Source: EMS 12-Lead - Category: Cardiology Authors: Tags: Original Articles Vince DiGiulio Source Type: research