Self-reactive CD4+ IL-3+ T cells amplify autoimmune inflammation in myocarditis by inciting monocyte chemotaxis

This study defines a mechanism that orchestrates inflammation in myocarditis, describes a previously unknown function for IL-3, and identifies IL-3 as a potential therapeutic target in patients with myocarditis.

Source: The Journal of Experimental Medicine - February 4, 2019 Category: Internal Medicine Authors: Anzai, A., Mindur, J. E., Halle, L., Sano, S., Choi, J. L., He, S., McAlpine, C. S., Chan, C. T., Kahles, F., Valet, C., Fenn, A. M., Nairz, M., Rattik, S., Iwamoto, Y., Fairweather, D., Walsh, K., Libby, P., Nahrendorf, M., Swirski, F. K. Tags: Autoimmunity, Cardiovascular Biology, Innate Immunity and Inflammation Articles Source Type: research