Class II transactivator (CIITA) mediates IFN-γ induced eNOS repression by enlisting SUV39H1

In conclusion, our data reveal a novel role for CIITA in endothelial cells and present SUV39H1 as a druggable target in the intervention of endothelial dysfunction.

Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - February 2, 2019 Category: Genetics & Stem Cells Source Type: research