How air influences radiation dose deposition in multiwell culture plates: a Monte Carlo simulation of radiation geometry

The objective of our study was to quantify this error in culture plates with multiple wells. Radiation conditions were simulated with the GAMOS code, based on the GEANT4 code, and this was compared with a simulation performed with PENELOPE and measured data. We observed a slight underdosage of ~4% on the most superficial half of the culture medium. We believe that this underdosage does not have a significant effect on the dose received by culture cells deposited in a monolayer and adhered to the base of the wells.

Source: Journal of Radiation Research - September 10, 2014 Category: Physics Authors: Sabater, S., Berenguer, R., Honrubia-Gomez, P., Rivera, M., Nunez, A., Jimenez-Jimenez, E., Martos, A., Ramirez-Castillejo, C. Tags: Technology Source Type: research