Clinical oxygen enhancement ratio of tumors in carbon ion radiotherapy: the influence of local oxygenation changes

In conclusion, our results suggest that hypoxia can influence the outcome of carbon ion radiotherapy because of the non-negligible oxygen effect at the low LETs in the SOBP. However, if LOCs occur, a relatively high level of tumor control probability is achievable with a large range of fractionation schedules for tumors with hypoxic subvolumes, but both hyperfractionation and hypofractionation should be pursued with caution.

Source: Journal of Radiation Research - September 10, 2014 Category: Physics Authors: Antonovic, L., Lindblom, E., Dasu, A., Bassler, N., Furusawa, Y., Toma-Dasu, I. Tags: Oncology Source Type: research