Localisation of Luminal Epithelium Edge in Digital Histopathology Images of IHC Stained Slides of Endometrial Biopsies

Diagnosis of recurrent miscarriage due to abnormally high number of uterine Natural Killer (uNK) cells has recently been made possible by a protocol devised by Quenby et al. [1]. The diagnosis involves detection and counting of stromal and uNK cell nuclei in endometrial biopsy slides immunohistochemically stained with Haematoxylin for staining cell nuclei and CD56 as a marker for the uNK cells. However, manual diagnosis is a laborious process, fraught with subjective errors. In this paper, we present a novel method for detection of uterine Natural Killer (uNK) cells in the human female uterus lining and localisation of the luminal epithelium edge in endometrial biopsies.
Source: Computerized Medical Imaging and Graphics - Category: Radiology Authors: Source Type: research