Targets of anti-glucocorticoid therapy for stress-related diseases.

Targets of anti-glucocorticoid therapy for stress-related diseases. Recent Pat CNS Drug Discov. 2013 Apr;8(1):79-87 Authors: Martocchia A, Stefanelli M, Falaschi GM, Toussan L, Rocchietti March M, Raja S, Romano G, Falaschi P Abstract The stress response during chronic conditions increases vulnerability to diseases through the activation of adaptive systems, in particular, the hypothalamus-pituitary-adrenal (HPA) axis. Dysregulation in HPA activity (central and peripheral) has been reported in chronic diseases, like metabolic syndrome, type-2 diabetes mellitus, atherosclerosis-related disease, essential hypertension, dementia, depression, particularly during comorbid conditions. Different targets of anti-glucocorticoid treatment have been proposed, acting at supra-hypothalamic, HPA axis, glucocorticoid receptor and post-receptor levels. The recent promising patents on the therapy against glucocorticoid-mediated damage will be presented and discussed. PMID: 23489288 [PubMed - indexed for MEDLINE]
Source: Recent Patents on CNS Drug Discovery - Category: Drugs & Pharmacology Tags: Recent Pat CNS Drug Discov Source Type: research