Targets of anti-glucocorticoid therapy for stress-related diseases.
Targets of anti-glucocorticoid therapy for stress-related diseases.
Recent Pat CNS Drug Discov. 2013 Apr;8(1):79-87
Authors: Martocchia A, Stefanelli M, Falaschi GM, Toussan L, Rocchietti March M, Raja S, Romano G, Falaschi P
Abstract
The stress response during chronic conditions increases vulnerability to diseases through the activation of adaptive systems, in particular, the hypothalamus-pituitary-adrenal (HPA) axis. Dysregulation in HPA activity (central and peripheral) has been reported in chronic diseases, like metabolic syndrome, type-2 diabetes mellitus, atherosclerosis-related disease, essential hypertension, dementia, depression, particularly during comorbid conditions. Different targets of anti-glucocorticoid treatment have been proposed, acting at supra-hypothalamic, HPA axis, glucocorticoid receptor and post-receptor levels. The recent promising patents on the therapy against glucocorticoid-mediated damage will be presented and discussed.
PMID: 23489288 [PubMed - indexed for MEDLINE]
Source: Recent Patents on CNS Drug Discovery - Category: Drugs & Pharmacology Tags: Recent Pat CNS Drug Discov Source Type: research
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