IL-10 is associated with increased mu-opioid receptor levels in major depressive disorder

ConclusionThe results show that MOR levels may function as a possible component of the CIRS whilst there is no evidence that β-EP and EM-2 may modify the IRS. The significant correlation between MOR levels and IL-10 may be explained through central activation of the HPA-axis and increased B-cell numbers expressing MOR as a response to cytokine over-secretion in MDD.

Source: European Psychiatry - January 22, 2019 Category: Psychiatry Source Type: research