Inhibition of antigen presentation by Brucella: many more than many ways

Publication date: Available online 21 January 2019Source: Microbes and InfectionAuthor(s): Paula Barrionuevo, Guillermo H. GiambartolomeiAbstractBrucella infection activates the immune system and favors the differentiation of CD4+ and CD8+ T cells. To persist during a long time inside macrophages evading immune surveillance of these T cells the pathogen must exploit different evasion strategies. We review the mechanisms whereby Brucella, through TLR signaling, inhibits MHC class I and II antigen presentation, allowing infected macrophages to become effective niches for Brucella survival.
Source: Microbes and Infection - Category: Infectious Diseases Source Type: research