TRPV1 antagonist attenuates postoperative hypersensitivity by central and peripheral mechanisms

Conclusions:
Our experiments suggest that both peripheral and spinal cord TRPV1 receptors are involved in increased cutaneous sensitivity following surgical incision. The analgesic effect of the TRPV1 receptor antagonist was especially evident in the reduction of thermal hyperalgesia. The activation of TRPV1 receptors represents an important mechanism in the development of postoperative hypersensitivity.

Source: Molecular Pain - November 17, 2014 Category: Molecular Biology Authors: Eva UchytilovaDiana SpicarovaJiri Palecek Source Type: research