Differential role of STIM1 and STIM2 during transient inward ( T in ) current generation and the maturation process in the Xenopus oocyte

Conclusions:
It was found that STIM2, but not STIM1, was essential in both responses, and T
in currents and GVBD were strongly reduced or eliminated in cells devoid of STIM2; STIM1 knockdown had no effect on the maturation process, but it reduced the T
in response by 15 to 70%. Thus, the endogenous SOCE response in Xenopus oocytes depended mainly on STIM2, and its expression was necessary for entry into meiosis induced by progesterone.

Source: BMC Physiology - November 15, 2014 Category: Physiology Authors: Barbara Serrano-FloresEdith GarayFrancisco Vázquez-CuevasRogelio Arellano Source Type: research