Acute liver function decompensation in a patient with sickle cell disease managed with exchange transfusion and endoscopic retrograde cholangiography

We describe a case of a 16-year-old female with homozygous sickle cell anemia who presented to the emergency room with fatigue, malaise, dark urine, lower back pain, scleral icterus and jaundice. She was found to have marked hyperbilirubinemia, which persisted after exchange transfusion. Because of the concomitant presence of gallstones and choledocholithiasis, the patient underwent endoscopic ultrasound and laparoscopic cholecystectomy followed by endoscopic retrograde cholangiography and sphincterotomy.

Source: Therapeutic Advances in Gastroenterology - July 1, 2014 Category: Gastroenterology Authors: Papafragkakis, H., Ona, M. A., Changela, K., Sadanandan, S., Jelin, A., Anand, S., Duddempudi, S. Tags: Reviews Source Type: research