Progress of Sonic-Spray Ionization Mass Spectrometry and Its Applications

Publication date: January 2019Source: Chinese Journal of Analytical Chemistry, Volume 47, Issue 1Author(s): Yue-Guang LYU, Hua BAI, Wen-Tao LI, Jing-Kui YANG, Yu-Jian HE, Qiang MAAbstractSonic-spray ionization (SSI) is a previously developed soft ionization technique which does not need auxiliary methods such as voltage, heating, laser, or corona discharge. Spray ionization can be achieved under normal temperature and atmospheric pressure by inputting high-speed gas coaxial within the capillary. As an atmospheric pressure ion source, this technique was widely used as the interface of liquid chromatography-mass spectrometry at the beginning of its development. Based on the principles of sonic-spray ionization, a variety of easy ambient sonic-spray ionization derived techniques have been developed, which can be used for the in-situ, rapid and real-time analysis of samples with little or without any sample pretreatment. In this paper, the principless and characteristics of sonic-spray ionization were elaborated, and the progress of its application in life sciences, food safety, forensic chemistry, reaction monitoring, and other related fields were summarized.Graphical AbstractSonic-spray ionization is an ionization technique that relies solely on a high-velocity stream of nebulizing gas coaxial to spray capillary and with no assistance of externally applied ionization energy. In this paper, the principles and characteristics of sonic-spray ionization were elaborated, and the pro...
Source: Chinese Journal of Analytical Chemistry - Category: Chemistry Source Type: research