USP4 deficiency exacerbates hepatic ischaemia/reperfusion injury via TAK1 signalling

In conclusion, our study demonstrates that USP4 deficiency plays a detrimental role in hepatic I/R injury by promoting activation of the TAK1/JNK signalling pathways. Modulation of this axis may be a novel strategy to alleviate the pathological process of hepatic I/R injury.

Source: Clinical Science - January 8, 2019 Category: Biomedical Science Authors: Zhou, J., Qiu, T., Wang, T., Chen, Z., Ma, X., Zhang, L., Zou, J. Tags: PublishAheadOfPrint Source Type: research