TGR5 activation induces cytoprotective changes in the heart and improves myocardial adaptability to physiologic, inotropic, and pressure ‐induced stress in mice

ConclusionsBile acids, specifically TGR5 agonists, induce cytoprotective changes in the heart and improve myocardial response to physiologic, inotropic, and hemodynamic stress in mice. TGR5 plays a critical role in myocardial adaptability, and TGR5 activation may represent a potentially attractive treatment option in heart failure.

Source: Cardiovascular Therapeutics - September 12, 2018 Category: Cardiology Authors: Zeena Eblimit, Sundararajah Thevananther, Saul J. Karpen, Heinrich Taegtmeyer, David D. Moore, Luciano Adorini, Daniel J. Penny, Moreshwar S. Desai Tags: ORIGINAL RESEARCH ARTICLE Source Type: research