Hydrogen peroxide and nitric oxide induce anticontractile effect of perivascular adipose tissue via renin angiotensin system activation

ConclusionFor the first time in the literature, our results show the presence of Mas and AT2 receptors, as well as, nitric oxide synthase on perivascular adipose tissue. Furthermore, our results show the involvement of Mas and AT2 receptors and consequently nitric oxide synthase activation in the anti-contractile effect exerted by perivascular adipose tissue.Graphical abstractRepresentative figure of the PVAT vasodilator pathway. Mas or AT2 receptors activation in PVAT culminates in the PI3K – Akt pathway and NOS activation that induce the production NO and H2O2 from eNOS and nNOS.

Source: Nitric Oxide - January 4, 2019 Category: Chemistry Source Type: research