Autophagy and its regulation by ginseng components

Publication date: Available online 2 January 2019Source: Journal of Ginseng ResearchAuthor(s): Nurinanda Prisky Qomaladewi, Mi-Yeon Kim, Jae Youl ChoAbstractAutophagy is the sequential process whereby cell components are degraded, which can occur due to nutrient deprivation. Its regulation has an essential role in many diseases, functioning in both cell survival and cell death. Autophagy starts when mTORC1 is inhibited, resulting in the activation of several complexes to form a cargo that fuses with a lysosome, where it undergoes degradation. Here we describe a plant extract that is well known in Korea, namely Korean ginseng extract; we studied how its derivatives and metabolites can regulate autophagy and thus mediate the pathogenesis of certain diseases.

Source: Journal of Ginseng Research - January 2, 2019 Category: Complementary Medicine Source Type: research