Atlas-based anatomical modeling and analysis of heart disease

Publication date: Available online 31 July 2014 Source:Drug Discovery Today: Disease Models Author(s): Pau Medrano-Gracia , Brett R. Cowan , Avan Suinesiaputra , Alistair A. Young Heart shape and function are major determinants of disease severity and predictors of future morbidity and mortality. Many studies now rely on non-invasive cardiac imaging techniques to quantify structural and functional changes. Statistical anatomical modeling of heart shape and motion provides a new tool for the quantification and evaluation of heart disease. This review surveys recent progress in the evaluation of statistical shape measures across populations and sub-cohorts, and highlights collaborative efforts to facilitate data sharing and atlas-based shape analysis. Graphical abstract
Source: Drug Discovery Today: Disease Models - Category: Drugs & Pharmacology Source Type: research