Computational models for predictive cardiac ion channel pharmacology

Publication date: Available online 5 August 2014 Source:Drug Discovery Today: Disease Models Author(s): Vladimir Yarov-Yarovoy , Toby W. Allen , Colleen E. Clancy A wealth of experimental data exists describing the elementary building blocks of complex physiological systems. However, it is increasingly apparent in the biomedical sciences that mechanisms of biological function cannot be observed or readily predicted via study of constituent elements alone. This is especially clear in the longstanding failures in prediction of effects of drug treatment for heart rhythm disturbances. These failures stem in part from classical assumptions that have been made in cardiac antiarrhythmic drug development – that a drug operates by one mechanism via one target receptor that arises from one gene.
Source: Drug Discovery Today: Disease Models - Category: Drugs & Pharmacology Source Type: research