Fish: a suitable system to model human bone disorders and discover drugs with osteogenic or osteotoxic activities

Publication date: Available online 15 September 2014 Source:Drug Discovery Today: Disease Models Author(s): Vincent Laizé , Paulo J. Gavaia , M. Leonor Cancela This review discusses the suitability and advantages of teleost fish for studying underlying mechanisms of normal and pathological development and mineralization of vertebrate skeleton, presents a selection of zebrafish mutants and transgenic lines modeling human skeletal diseases and highlights currently available fish systems for identifying and characterizing novel osteogenic and osteotoxic molecules.
Source: Drug Discovery Today: Disease Models - Category: Drugs & Pharmacology Source Type: research