Six new dammarane-type triterpene saponins from Panax ginseng flower buds and their cytotoxicity

Publication date: Available online 30 December 2018Source: Journal of Ginseng ResearchAuthor(s): Ke-Ke Li, Sha-Sha Li, Fei Xu, Xiao-Jie GongAbstractBackgroundPanax ginseng has been used for a variety of medical purposes in eastern countries for more than two thousand years. From the extensive experiences accumulated in its long medication use history and the substantial strong evidences in modern researches, we know that ginseng has various pharmacological activities, such as anti-tumor, anti-diabetic, anti-oxidant and protecting cardiovascular system effects. The active chemical constituents of ginseng, ginsenosides, are rich in structural diversity and exhibit a wide range of biological activities.MethodsGinsenosides constituents from P. ginseng flower buds were isolated and purified by various chromatographic methods, and their structures were identified by spectroscopic analysis and comparison with the reported data. The MTT method was used to test their cytotoxic effects on three human cancer cell lines.Results and conclusionSix ginsenosides, namely 6'–malonyl formyl ginsenoside F1 (1), 3β–acetoxyl ginsenoside F1 (2), ginsenoside Rh24 (6), ginsenoside Rh25 (7), 7β–hydroxyl ginsenoside Rd (8) and ginsenoside Rh26 (10) were isolated and elucidated as new compounds, together with four known compounds (3–5, 9). Compound 1 exhibited moderate cytotoxic activities against HL-60, MGC80-3 and Hep-G2 with IC50 values of 16.74, 29.51 and 20.48 μM, respectively. A tentati...
Source: Journal of Ginseng Research - Category: Complementary Medicine Source Type: research