Diastolic function alteration mechanisms in physiologic hypertrophy versus pathologic hypertrophy are elucidated by model-based Doppler E-wave analysis

Publication date: Available online 12 November 2014 Source:Journal of Exercise Science & Fitness Author(s): Simeng Zhu , Thomas Morrell , Astrid Apor , Béla Merkely , Hajnalka Vágó , Attila Tóth , Erina Ghosh , Sándor J. Kovács Athletic training can result in increased left ventricular (LV) wall thickness, termed physiologic hypertrophy (PhH). By contrast, pathologic hypertrophy (PaH) can be due to hypertension, aortic stenosis, or genetic mutation causing hypertrophic cardiomyopathy (HCM). Because morphologic (LV dimension, wall thickness, mass, etc.) and functional index similarities (LV ejection fraction, cardiac output, peak filling rate, etc.) limit diagnostic specificity, ability to differentiate between PhH and PaH is important. Conventional echocardiographic diastolic function (DF) indexes have limited ability to differentiate between PhH and PaH and cannot provide information on chamber property (stiffness and relaxation). We hypothesized that kinematic model-based DF assessment can differentiate between PhH and PaH and, by providing chamber properties, has even greater value compared with conventional metrics. For validation, we assessed DF in the following three age-matched groups: pathologic (HCM) hypertrophy (PaH, n = 14), PhH (Olympic rowers, PhH, n = 21), and controls (n = 21). Magnetic resonance imaging confirmed presence of both types of hypertrophy and determined LV mass and chamber size. Model-based indexes, chamber stiffness...
Source: Journal of Exercise Science and Fitness - Category: Sports Medicine Source Type: research