Vasodilatory Efficacy and Impact of Papaverine on Endothelium in Radial Artery Predilatation for CABG Surgery: in Search for Optimal Concentration
Objective: The aim of this study was to compare the efficacy of two different papaverine
concentrations (0.5 mg/ml and 2 mg/ml) for vasospasm prevention and their
impact on endothelium integrity.Methods: We have studied distal segments of radial arteries obtained by no-touch
technique from coronary artery bypass graft (CABG) patients (n=10). The
vasodilatory effect of papaverine (concentrations of 0.5 mg/ml and 2 mg/ml)
was assessed in vitro, in isometric tension studies using
ex vivo myography (organ bath technique) and arterial
rings precontracted with potassium chloride (KCl) and phenylephrine. The
impact of papave ...
Source: Brazilian Journal of Cardiovascular Surgery - Category: Cardiology Source Type: research
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