Methoxphenidine: a designer dissociative drug

3 out of 5 stars Acute toxicity associated with the recreational use of the novel dissociative psychoactive substance methoxphenidine. Hofer KE et al. Clin Toxicol 2014 Oct 28 [Epub ahead of print] Abstract Methoxphenidine  (MXP) is a dissociative drug with actions apparently similar to those of phencyclidine (PCP), ketamine, and methoxetamine (MXE). It is often sold as a “research chemical” and labelled as “Not for Human Consumption.” The pharmacology and toxicology of MXP has not been well studied. Anecdotal reports on some drug forums describe anterograde amnesia and prolonged duration of effects (up to 18 hours). Since it is as yet not highly regulated, MXP seems to be used more frequently as the other dissociative agents are put under legal restrictions. This case report, from Switzerland, describes a 53-year-old man who presented after an apparent MXP ingestion, later confirmed in the laboratory. Presenting manifestations included somnolence, confusion, echolalia, miosis, hypertension, tachycardia, nystagmus, and apparent seizure activity. The authors conclude: . . .methoxphenidine appears to have a similar acute toxicity profile to other arylcyclohexylamines, such as PCP, ketamine and MXE. On the basis of the very limited evidence available, management of patients presenting with acute toxicity related to methoxphenidine use should be as for other dissociative drugs.” Related posts: Methoxetamine: a ketamine analog that is NOT bladder ...
Source: The Poison Review - Category: Toxicology Authors: Tags: Medical case report designer drug dissociative ketamine methoxetamine pcp phencyclidine Source Type: news