Nitric oxide synthase inhibitors 1400W and L-NIO inhibit angiogenesis pathway of colorectal cancer

ConclusionNOS inhibitors could suppress colorectal cancer cell growth and migration, likely via suppressing the angiogenesis pathway.Graphical abstractNO is implicated in angiogenesis, a hallmark for CRC. By inhibiting NOS using 1400W or L-NIO, CRC cell growth and migration were suppressed, with simultaneous inhibition of the angiogenic pathway.
Source: Nitric Oxide - Category: Chemistry Source Type: research