Primary mucinous adenocarcinoma of the renal pelvis with carcinoma in situ in the ureter

Publication date: March 2014 Source:Journal of the Egyptian National Cancer Institute, Volume 26, Issue 1 Author(s): Mahmoud Abbas , Mario W. Kramer , Tilmann Spieker , Thomas R.W. Herrman , Axel S. Merseburger , Klaus-Michael Müller , Marcus A. Kuczyk , Jan U. Becker , Hans-Heinrich Kreipe Primary epithelial tumor of the renal pelvis is rare and only 100 cases are reported in the literature [1]. Histological examination of the tumor showed glands, cysts, and papillae lined by pseudostratified columnar epithelium with hyperchromatic nuclei. Scattered signet ring-type cells were also seen floating in large pools of extracellular mucin. Sections from the ureter showed a component of adenocarcinoma in situ. No invasive tumor was identified in ureteric tissue. One case was reported with carcinoma in situ of the ureter (2). Immunohistochemically: The tumor showed positivity for CK7, CK20, CK8/18, GATA-3, MSH-2, MSH-6, MLH-1, Ber-EP4, and S-100-P with focal positivity for CDX-2, weak positivity for PMS-2 and negativity in TTF-1 and Her-2. Molecular pathological analysis revealed microsatellite stability and without mutation in K-ras-gene. Thus, a diagnosis of mucinous adenocarcinoma of the renal pelvis with in situ adenocarcinoma of the ureter was made.
Source: Journal of the Egyptian National Cancer Institute - Category: Cancer & Oncology Source Type: research