Hereditary breast and ovarian Cancer syndrome: Considering the Complexities

Hereditary Breast and Ovarian Cancer syndrome (HBOC) is a well-described hereditary cancer predisposition syndrome caused by mutations in BRCA1 and BRCA2. Several studies have provided lifetime breast cancer risk estimates for women with HBOC, and most have suggested a risk between 50 and 80%.1 Men with BRCA mutations have a risk of up to 8% of developing breast cancer in their lifetimes.2 In females, the risk of developing breast cancer appears to be slightly higher in carriers of BRCA1 mutations compared to carriers of BRCA2 mutations, while the opposite is true with regard to the risks for male breast cancer.

Source: Current Problems in Cancer - October 31, 2014 Category: Cancer & Oncology Authors: Leigha Senter Source Type: research