LC-MS data processing with MAVEN: a metabolomic analysis and visualization engine.

LC-MS data processing with MAVEN: a metabolomic analysis and visualization engine.
Curr Protoc Bioinformatics. 2012 Mar;Chapter 14:Unit14.11
Authors: Clasquin MF, Melamud E, Rabinowitz JD
Abstract
MAVEN is an open-source software program for interactive processing of LC-MS-based metabolomics data. MAVEN enables rapid and reliable metabolite quantitation from multiple reaction monitoring data or high-resolution full-scan mass spectrometry data. It automatically detects and reports peak intensities for isotope-labeled metabolites. Menu-driven, click-based navigation allows visualization of raw and analyzed data. Here we provide a User Guide for MAVEN. Step-by-step instructions are provided for data import, peak alignment across samples, identification of metabolites that differ strongly between biological conditions, quantitation and visualization of isotope-labeling patterns, and export of tables of metabolite-specific peak intensities. Together, these instructions describe a workflow that allows efficient processing of raw LC-MS data into a form ready for biological analysis.
PMID: 22389014 [PubMed - indexed for MEDLINE]

Source: Current Protocols in Bioinformatics - November 12, 2014 Category: Bioinformatics Tags: Curr Protoc Bioinformatics Source Type: research