Arsenic trioxide encapsulated liposomes prepared via copper acetate gradient loading method and its antitumor efficiency

In conclusion, ATO can be effectively encapsulated into liposomes by remote loading method via Cu(OAc)2 gradients; the co-administration of ATO and Cu(II) via liposomal formulation may find wide applications in the treatment of various tumors.Graphical abstractCo-encapusulation of Arsenic trioxide and Cu (II) in to lipsomese through copper acetate (Cu(OAc)2) gradients displayed high tumor inhibition in S180 solid tumor-bearing mice.
Source: Asian Journal of Pharmaceutical Sciences - Category: Drugs & Pharmacology Source Type: research