Is it possible to combine photodynamic therapy and application of dinitrosyl iron complexes in the wound treatment?

Publication date: Available online 14 December 2018Source: Nitric OxideAuthor(s): Anna B. Solovieva, Anatoly F. Vanin, Anatoly B. Shekhter, Nikolay N. Glagolev, Nadezhda A. Aksenova, Vasak D. Mikoyan, Svetlana L. Kotova, Tatyana G. Rudenko, Alexey Fayzullin, Peter S. TimashevAbstractWe have studied the effect of interactions between dinitrosyl iron complexes with thiol-containing ligands (DNIC-TL) and diglucamine salt of chlorine e6 (photoditazine, PD) on the rate of photosensitized oxidation of a model organic substrate – tryptophan – in the presence and absence of an amphiphilic polymer, Pluronic F127, as well as on the DNIC-TL and PD photostability. Using EPR and UV spectroscopy, we determined the rate constants for photodegradation of mono- and dinuclear DNIC-TL and PD, respectively. The presence of the photosensitizer and Pluronic F127 has been shown to have a negligible effect on the rate of photodestruction of mono- and dinuclear DNIC-TL, taking into account the changing DNIC-TL and PD concentrations in the photoexcitation conditions. At the same time, in the DNIC-TL presence, the rate of PD photodestruction increases, however, addition of Pluronic F127 leads to a decrease in the rate constant of PD photodestruction. The latter circumstance creates an opportunity for a simultaneous application of DNIC-TL and photodynamic therapy in the wound treatment without losing the PDT efficiency. Indeed, photodynamic therapy in combination with DNIC-TL facilitated skin wound ...
Source: Nitric Oxide - Category: Chemistry Source Type: research