Somatic and germline genomics in paediatric acute lymphoblastic leukaemia
Somatic and germline genomics in paediatric acute lymphoblastic leukaemiaSomatic and germline genomics in paediatric acute lymphoblastic leukaemia, Published online: 13 December 2018; doi:10.1038/s41571-018-0136-6Herein, advances in our understanding of the genomic landscape of childhood acute lymphoblastic leukaemia (ALL), encompassing both somatic and germline alterations, are reviewed. The clinical implications of these alterations, particularly those in the germ line, are discussed with regard to susceptibility to ALL, treatment responses and therapy-related toxicities.
Source: Nature Clinical Practice Oncology - Category: Cancer & Oncology Authors: Ching-Hon Pui Kim E. Nichols Jun J. Yang Source Type: research
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